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New posts, Uncategorized /
LSD tshirt

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Better site specificity for Photoaffinity Labeling

New posts, Site-specific conjugation /

I usually do not like to write about photoaffinity labeling reagents because of their indiscriminate nature. But this publication from the lab of Dr. Christina Woo in Harward. They were able to develop Cyclobutane Diazirine tags that can label Carboxylic Acids on the protein with variety of functionalities with pretty respectable efficiency (5-25%)!  They used

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New way to add Maleimide to Oligos

Uncategorized /

For those scientists that frequently have to conjugate Oligonucleotides to proteins it is always important to have a procedure for efficient activation of the Oligonucleotide. Usually it is done with Bifunctional cross-linker because maleimide functionality cannot be introduced directly during the solid-phase oligonucleotide synthesis, But work from Dr. Kurt V. Gothelf at the Aarhus University

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Very unusual way to add Azide to Tyrosine

ADC, Site-specific conjugation /

This method comes to us from Switzerland’s very own Ecole Polytechnique Fédérale de Lausanne, group of Dr. Waser. They decided to functionalize Tyrosine using Hypervalent Iodine compounds. To  be precise, they used ethynylbenziodoxolones (EBX). It was pretty selective to Tyrosine, compared to other nucleophilic residues, and was slightly reactive towards cysteine. But, if there is

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Very unusual method of turning Tryptophan into click-reactive handle

Site-specific conjugation /

  This research comes to us from very reputable group of Dr. Yiyi Weng at Zhejiang University of Technology. This paper shows how to turn any Tryptophan into strange tertiary azide heterocycle with about 87% efficiency. Could be useful if no other functionalization methods are available. I am not sure how reactive this azide will

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Very Interesting Alkyne Reaction

Site-specific conjugation /

Here comes new modification of the Alkyne. Is this the new click chemistry? Through a modified Kinugasa reaction, a novel method of amidation on terminal oligo alkyne conjugates by copper-promoted oxidation with nitrones has been developed. Unprotected bifunctional carboxylic acid–amine reagents can be transformed directly to the respective amide products under these edited Kinugasa reaction

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Lysine-Directed Site-Selective Bioconjugation for the Creation of Radioimmunoconjugates

ADC /
bc2c

Samantha M. SarrettSamantha M. SarrettDepartment of Chemistry, Hunter College, City University of New York, New York, New York 10065, United StatesPh.D. Program in Biochemistry, Graduate Center of the City University of New York, New York, New York 10016, United StatesDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, United StatesMore by

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