October 2022

New way to add Maleimide to Oligos

For those scientists that frequently have to conjugate Oligonucleotides to proteins it is always important to have a procedure for efficient activation of the Oligonucleotide. Usually it is done with Bifunctional cross-linker because maleimide functionality cannot be introduced directly during the solid-phase oligonucleotide synthesis, But work from Dr. Kurt V. Gothelf at the Aarhus University […]

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Very unusual way to add Azide to Tyrosine

This method comes to us from Switzerland’s very own Ecole Polytechnique Fédérale de Lausanne, group of Dr. Waser. They decided to functionalize Tyrosine using Hypervalent Iodine compounds. To  be precise, they used ethynylbenziodoxolones (EBX). It was pretty selective to Tyrosine, compared to other nucleophilic residues, and was slightly reactive towards cysteine. But, if there is

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