February 2025

DBCO strikes again….

ADC, Site-specific conjugation /

As part of our ongoing weekly tradition, we are highlighting notable and unconventional bioconjugation research. Today, I would like to discuss a recent publication from Dr. Pentelute’s lab at MIT, available at DOI: 10.1002/anie.201800860. This study bridges the gap between purely chemical bioconjugation strategies and chemoenzymatic approaches. The researchers developed a miniature enzyme, composed of […]

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Unusual acylation reagent based on DBCO

Uncategorized /

Everybody thinks about DBCO functionality as a copper-less click chemistry partner. But the authors of this paper https://doi.org/10.1002/anie.202009408 have demonstrated strange behavior of very familiar reagent under specific conditions and in the presence of the Silver Triflate catalyst (AgNTf2). This work comes from the  group of Prof. W. Huang at University of Chinese Academy of Sciences in

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