Dr. Dmitriy Gremyachinskiy
Bioconjugation Enthusiast
About us
Hello and welcome to Biocovalent, a blog about cool and unusual Bioconjugation strategies.
My name is Dmitriy Gremyachinskiy. My scientific passion is Bioconjugation and Bioconjugation Process Development.
I have over 12 years of experience in the Bioconjugation space and have experience conjugating Oligonucleotides, Antibodies and Enzymes. I have worked mostly in Genetic Sequencing and Proteomics industry.
I worked for ThermoFisher, Roche, Nautilus Bio, Illumina and currently Quantum-Si. I have few patents that describe novel bioconjugation methods.
In this blog we will be discussing new and interesting developments in the field of Bioconjugation. Please do not hesitate to reach out and/or subscribe to the blog.
Goals of the Blog:
” To inform the scientific community about new and interesting methods for Bioconjugation. Bring new Bioconjugation research results into the spotlight.”
Featured Articles
In this blog we will be discussing new and interesting developments in the field of Bioconjugation.
11C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain
Thiocyanate (SCN–) alters the potency of certain agonists for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, and dysfunctions in AMPA receptor signaling are considered to underlie a number of neurological diseases.
Cyclopentadiene as a Multifunctional Reagent for Normal- and Inverse-Electron Demand Diels–Alder Bioconjugation
Optimizing the Diels–Alder (DA) reaction for aqueous coupling has resulted in practical methods to link molecules such as drugs and diagnostic agents to proteins.
Lysine-Directed Site-Selective Bioconjugation for the Creation of Radioimmunoconjugates
The synthesis of radioimmunoconjugates via the stochastic attachment of bifunctional chelators to lysines can yield heterogeneous products with suboptimal in vitro and in vivo behavior. In response to this, several site-selective approaches to bioconjugation have been developed, yet each has intrinsic drawbacks, such as the need for expensive reagents or the complexity of incorporating unnatural amino acids into IgGs.