As part of our ongoing weekly tradition, we are highlighting notable and unconventional bioconjugation research. Today, I would like to discuss a recent publication from Dr. Pentelute’s lab at MIT, available at DOI: 10.1002/anie.201800860. This study bridges the gap between purely chemical bioconjugation strategies and chemoenzymatic approaches. The researchers developed a miniature enzyme, composed of […]
DBCO strikes again…. Read More »
This method comes to us from Switzerland’s very own Ecole Polytechnique Fédérale de Lausanne, group of Dr. Waser. They decided to functionalize Tyrosine using Hypervalent Iodine compounds. To be precise, they used ethynylbenziodoxolones (EBX). It was pretty selective to Tyrosine, compared to other nucleophilic residues, and was slightly reactive towards cysteine. But, if there is
Very unusual way to add Azide to Tyrosine Read More »
Samantha M. SarrettSamantha M. SarrettDepartment of Chemistry, Hunter College, City University of New York, New York, New York 10065, United StatesPh.D. Program in Biochemistry, Graduate Center of the City University of New York, New York, New York 10016, United StatesDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, United StatesMore by
Lysine-Directed Site-Selective Bioconjugation for the Creation of Radioimmunoconjugates Read More »