Everybody thinks about DBCO functionality as a copper-less click chemistry partner. But the authors of this paper https://doi.org/10.1002/anie.202009408 have demonstrated strange behavior of very familiar reagent under specific conditions and in the presence of the Silver Triflate catalyst (AgNTf2). This work comes from the group of Prof. W. Huang at University of Chinese Academy of Sciences in […]
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For those scientists that frequently have to conjugate Oligonucleotides to proteins it is always important to have a procedure for efficient activation of the Oligonucleotide. Usually it is done with Bifunctional cross-linker because maleimide functionality cannot be introduced directly during the solid-phase oligonucleotide synthesis, But work from Dr. Kurt V. Gothelf at the Aarhus University
New way to add Maleimide to Oligos Read More »